Blood urea nitrogen and serum creatinine are imperfect markers of kidney function because
they are influenced by many renal and nonrenal factors independent of kidney function. A …

Cytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic
agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide …

Many therapeutic regimens in cancer treatment carry the risk of causing or favoring the
development of osteoporosis. Therapies in which hypogonadism may occur are most …

Conventional chemotherapies remain the mainstay of treatment for many malignancies.
Kidney complications of these therapies are not infrequent and may have serious …

The aim of this multicentre study was to document the nephrotoxicity associated with
ifosfamide and evaluate risk factors in 148 children and young people with sarcomas who …

The successful treatment of pediatric malignancy by multimodality therapy has improved the
outcome for children with cancer. It has been estimated that 0.1% of individuals 20 years of …

Objective: To determine the incidence and characterize the occurrence of cardiac toxicity
with high-dose ifosfamide. Design: Retrospective chart review. Setting: Biomedical research …

Ifosfamide is an oxazaphosphorine alkylating agent with a broad spectrum of antineoplastic
activity. It is a prodrug metabolised in the liver by cytochrome P450 mixed-function oxidase …

The clinical use of antineoplastic drugs can be limited by different drug‐induced toxicities. Of
these, renal dysfunction may be one of the most troublesome in that it can be cumulative and …

Acute renal failure (ARF) is defined as a sudden decrease in glomerular filtration rate
leading to an acute rise in blood urea nitrogen and serum creatinine levels. It is a serious …