Biodegradable microspheres have been widely used in the field of medicine due to their
ability to deliver drug molecules of various properties through multiple pathways and their …

The osteochondral defect repair has been most extensively studied due to the rising
demand for new therapies to diseases such as osteoarthritis. Tissue engineering has been …

Dexamethasone (DEX) has been widely used to treat a variety of diseases, including
autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19 …

Background The regeneration and repair of articular cartilage remains a major challenge for
clinicians and scientists due to the poor intrinsic healing of this tissue. Since cartilage …

Successful regeneration of cartilage tissue at a clinical scale has been a tremendous
challenge in the past decades. Microcarriers (MCs), usually used for cell and drug delivery …

Osteochondral (OC) repair is an extremely challenging topic due to the complex biphasic
structure and poor intrinsic regenerative capability of natural osteochondral tissue. In …

Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds,
mainly due to the advantages of their chemical and physical properties. This review focuses …

Neutrophils serve as a key contributor to the pathophysiology of myocardial ischemia
reperfusion injury (MIRI), because the unregulated activation and infiltration of neutrophils …

Osteoarthritis (OA) is the most prevalent degenerative joint disease affecting millions of
people worldwide. Currently, clinical nonsurgical treatments of OA are only limited to pain …

Drug delivery for osteoarthritis (OA) treatment is a continuous challenge because of their
poor bioavailability and rapid clearance in joints. Intra-articular (IA) drug delivery is a …