The relationship between insulin and glucagon concentrations in non‐diabetic humans

MC Laurenti, P Arora, C Dalla Man… - Physiological …, 2022 - Wiley Online Library
Abnormal postprandial suppression of glucagon in Type 2 diabetes (T2DM) has been
attributed to impaired insulin secretion. Prior work suggests that insulin and glucagon show …

The Effect of Diabetes-Associated Variation in TCF7L2 on Postprandial Glucose Metabolism When Glucagon and Insulin Concentrations Are Matched

JD Adams, AM Egan, MC Laurenti… - Metabolic Syndrome …, 2022 - liebertpub.com
Background: The rs7903146 variant in the TCF7L2 gene is associated with defects in
postprandial insulin and glucagon secretion and increased risk of type 2 diabetes. However …

Diabetes-associated Genetic Variation in MTNR1B and Its Effect on Islet Function

M Vella, S Mohan, H Christie, KR Bailey… - Journal of the …, 2024 - academic.oup.com
Context Multiple common genetic variants have been associated with type 2 diabetes, but
the mechanism by which they predispose to diabetes is incompletely understood. One such …

The role of preproglucagon peptides in regulating β-cell morphology and responses to streptozotocin-induced diabetes

DM Arble, CR Hutch, H Hafner… - American Journal …, 2023 - journals.physiology.org
Insulin secretion from β-cells is tightly regulated by local signaling from preproglucagon
(Gcg) products from neighboring α-cells. Physiological paracrine signaling within the …

[PDF][PDF] Immunological profile of diabetic foot ulcers: update review

MMA Jassim, LN Abdul-Razzaq, MH Hussein - Muthanna Medical Journal, 2023 - iasj.net
The most frequent consequence of diabetes mellitus, diabetic foot ulcers frequently do not
heal and necessitate lower limb amputation. According to estimates, DFU accounts for 50 …

Modelli del controllo del glucagone sulla produzione endogena di glucosio

A TONELLO - thesis.unipd.it
The transition from prediabetes to Type 2 Diabetes Mellitus (T2DM) is characterized by
defects in insulin secretion and glucagon suppression in response to glucose. However …

Islet Hormone Secretion, Action and Interaction in Health and Disease

MC Laurenti - 2022 - search.proquest.com
Type 2 diabetes mellitus (T2DM) is a metabolic disease characterized by a dysregulation of
glucose homeostasis. The pathophysiology of this disease is complex characterized by a …