Abstract The Ral (Ras‐Like) signaling pathway plays an important role in the biology of
cells. A plethora of effects is regulated by this signaling pathway and its prooncogenic …

One requirement for establishing polarity within a cell is the asymmetric trafficking of
intracellular vesicles to the plasma membrane. This tightly regulated process creates spatial …

Extracellular vesicles are novel mediators of cell-cell communication. They are present in all
species and involved in physiological and pathological processes. One class of extracellular …

Cell-matrix adhesion regulates membrane trafficking controlling anchorage-dependent
signaling. While a dynamic Golgi complex can contribute to this pathway, its regulation by …

Arf1 belongs to the Arf family of small GTPases that localise at the Golgi and plasma
membrane. Active Arf1 plays a crucial role in regulating Golgi organisation and function. In …

The RAL proteins RALA and RALB belong to the superfamily of small RAS-like GTPases
(guanosine triphosphatases). RAL GTPases function as molecular switches in cells by …

The exocyst is a conserved octameric complex that physically tethers a vesicle to the plasma
membrane, prior to membrane fusion. It is important not only for secretion and membrane …

Tunneling nanotubes (TNTs) are membrane conduits that mediate long-distance
intercellular cross-talk in several organisms and play vital roles during development …

Phagocytosis is an essential element of the immune response, assuring the elimination of
pathogens, cellular debris, and apoptotic and tumoral cells. Activation of phagocytosis by the …

Various bacterial toxins circumvent host defenses through overproduction of cAMP. In a
previous study, we showed that edema factor (EF), an adenylate cyclase from Bacillus …