Sickle cell disease (SCD) is a group of inherited disorders caused by mutations in HBB,
which encodes haemoglobin subunit β. The incidence is estimated to be between 300,000 …

This chapter reviews how allosteric (heterotrophic) effectors and natural mutations impact
hemoglobin (Hb) primary physiological function of oxygen binding and transport. First, an …

Deformability is an essential feature of blood cells (RBCs) that enables them to travel
through even the smallest capillaries of the human body. Deformability is a function of (i) …

The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42
into amyloid fibrils and plaques has emerged as a central feature of the onset and …

Crystallization starts with nucleation and control of nucleation is crucial for the control of the
number, size, perfection, polymorphism, and other characteristics of crystalline materials …

Although the root cause of sickle cell disease is the polymerization of hemoglobin S (HbS) to
form fibers that make red cells less flexible, most drugs currently being assessed in clinical …

Alzheimer's disease (AD) is a neurodegenerative disease characterized by the presence of
cerebral amyloid plaque (reviewed by Selkoe, 1991), a highly ordered protein aggregate …

The formation of crystalline nanoparticles starts with nucleation and control of nucleation is
crucial for the control of the number, size, perfection, polymorph modification and other …

In the new edition of this successful and authoritative book, the thalassaemias are reviewed
in detail with respect to their clinical features, cellular pathology, molecular genetics …

With the global scope of sickle-cell disease, knowledge of the countless clinical
presentations and treatment of this disorder need to be familiar to generalists …