Wnt proteins are now recognized as one of the major families of developmentally important
signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the …

G protein-coupled receptors (GPCRs) are the largest family of membrane-bound receptors
and also the targets of many drugs. Understanding of the functional significance of the wide …

The Wnt signalling pathway is an ancient system that has been highly conserved during
evolution. It has a crucial role in the embryonic development of all animal species, in the …

▪ Abstract Wnt genes encode a large family of secreted, cysteine-rich proteins that play key
roles as intercellular signaling molecules in development. Genetic studies in Drosophila and …

The discovery of sequence homology between the cytoplasmic domains of Drosophila Toll
and human interleukin 1 receptors has sown the conviction that both molecules trigger …

Receptors for Wingless and other signalling molecules of the Wnt gene family have yet to be
identified. We show here that cultured Drosophila cells transfected with a novel member of …

The Wnt signaling pathway, named for its most upstream ligands, the Wnts, is involved in
various differentiation events during embryonic development and leads to tumor formation …

The vertebrate transcription factors TCF (T cell factor) and LEF (lymphocyte enhancer
binding factor) interact with β-catenin and are hypothesized to mediate Wingless/Wnt …

Background & Aims: In the intestine, the canonical Wnt signaling cascade plays a crucial
role in driving the proliferation of epithelial cells. Furthermore, aberrant activation of Wnt …

Summary Wnt ligands oligomerize Frizzled (Fzd) and Lrp5/6 receptors to control the
specification and activity of stem cells in many species. How Wnt signaling is selectively …