Peroxisome proliferator-activated receptor γ (PPARγ) is a widely expressed ligand-
modulated transcription factor that governs the expression of genes involved in …

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription
factors of the nuclear hormone receptor superfamily. The 3 PPAR isoforms (alpha, delta/beta …

Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory
neurons where it acts as a sensor for environmental irritants, including acrolein, and some …

PPARs (peroxisome-proliferator-activated receptors) are ligand-activated transcriptional
factor receptors belonging to the so-called nuclear receptor family. The three isoforms of …

Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that regulates Antioxidant
Response Element (ARE)-mediated transcription of a plethora of antioxidant and protective …

Oleic acid (OA) is released from brain phospholipids after cerebral ischaemia; however, its
role in ischaemic injury remains unknown. We hypothesised that OA has neuroprotective …

1. ABSTRACT A large body of evidence points to the positive effects of dietary
supplementation of acetyl-L-carnitine (ALC). Its use has shown health benefits in …

Inflammation is a known precipitator of neuronal death after cerebral ischemia. The
mechanisms that promote or curtail the start and spread of inflammation in brain are still …

Ischemic acute kidney injury (AKI) triggers expression of adaptive (protective) and
maladaptive genes. Agents that increase expression of protective genes should provide a …

As the resident immune cells of the central nervous system, microglia rapidly respond to
brain insults, including stroke and traumatic brain injury. Microglial activation plays a major …