Abstract Background The World Health Organization (WHO) Classification of Tumours, also
known as WHO Blue Books, represents an international standardised tool in the diagnostic …

Since the 1960s, paediatric oncologists have gradually become better organised in large
study groups and participation in clinical trials is today considered as the standard of care …

Medulloblastoma, a malignant childhood cerebellar tumour, segregates molecularly into
biologically distinct subgroups, suggesting that a personalized approach to therapy would …

Medulloblastoma, a malignant brain tumour primarily diagnosed during childhood, has
recently been the focus of intensive molecular profiling efforts, profoundly advancing our …

Summary SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …

The spectrum of tumours arising in childhood is fundamentally different from that seen in
adults, and they are known to be divergent from adult malignancies in terms of cellular …

Brain tumors remain one of the most difficult tumors to treat and, depending on the
diagnosis, have a poor prognosis. Of brain tumors, glioblastoma (GBM) is the most common …

Granule cells (GCs) are the most numerous cell type in the cerebellum and indeed, in the
brain: at least 99% of all cerebellar neurons are granule cells. In this review article, we first …

Diagnostics is the key in screening and treatment of cancer. As an emerging tool in precision
medicine, metabolic analysis detects end products of pathways, and thus is more distal than …

The chromatin remodeler SMARCA4/BRG1 is a key epigenetic regulator with diverse roles
in coordinating the molecular programs that underlie brain tumour development. BRG1 …