Akt in cancer: Mediator and more

S Revathidevi, AK Munirajan - Seminars in cancer biology, 2019 - Elsevier
Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Genetic landscape and biomarkers of hepatocellular carcinoma

J Zucman-Rossi, A Villanueva, JC Nault, JM Llovet - Gastroenterology, 2015 - Elsevier
Hepatocellular carcinoma (HCC) has emerged as a major cause of cancer-related death. Its
mortality has increased in Western populations, with a minority of patients diagnosed at …

Role of the microenvironment in the pathogenesis and treatment of hepatocellular carcinoma

V Hernandez–Gea, S Toffanin, SL Friedman, JM Llovet - Gastroenterology, 2013 - Elsevier
Hepatocellular carcinoma (HCC) is the most common primary liver tumor and the third
greatest cause of cancer-related death worldwide, and its incidence is increasing. Despite …

Pathogenic mechanisms in HBV-and HCV-associated hepatocellular carcinoma

A Arzumanyan, HM Reis, MA Feitelson - Nature Reviews Cancer, 2013 - nature.com
Hepatocellular carcinoma (HCC) is a highly lethal cancer, with increasing worldwide
incidence, that is mainly associated with chronic hepatitis B virus (HBV) and/or hepatitis C …

The role of signaling pathways in the development and treatment of hepatocellular carcinoma

S Whittaker, R Marais, AX Zhu - Oncogene, 2010 - nature.com
Hepatocellular carcinoma (HCC) is a highly prevalent, treatment-resistant malignancy with a
multifaceted molecular pathogenesis. Current evidence indicates that during …

Hepatocellular carcinoma pathogenesis: from genes to environment

PA Farazi, RA DePinho - Nature Reviews Cancer, 2006 - nature.com
Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Combining crocin and sorafenib improves their tumor-inhibiting effects in a rat model of diethylnitrosamine-induced cirrhotic-hepatocellular carcinoma

B Awad, AA Hamza, A Al-Maktoum, S Al-Salam, A Amin - Cancers, 2023 - mdpi.com
Simple Summary Liver cancer represents one of the most lethal forms of cancer, with
hepatocellular carcinoma (HCC) accounting for the majority of its incidences and deaths …

Expression and function of the epidermal growth factor receptor in physiology and disease

J Chen, F Zeng, SJ Forrester, S Eguchi… - Physiological …, 2016 - journals.physiology.org
The epidermal growth factor receptor (EGFR) is the prototypical member of a family of
membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated …

The inflammatory microenvironment in hepatocellular carcinoma: a pivotal role for tumor‐associated macrophages

D Capece, M Fischietti, D Verzella… - BioMed research …, 2013 - Wiley Online Library
Hepatocellular carcinoma (HCC) is one of the most common and aggressive human cancers
worldwide. HCC is an example of inflammation‐related cancer and represents a paradigm …

[PDF][PDF] Epidermal growth factor receptor inhibition attenuates liver fibrosis and development of hepatocellular carcinoma

BC Fuchs, Y Hoshida, T Fujii, L Wei, S Yamada… - …, 2014 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the most rapidly increasing cause of cancer‐related
mortality in the United States. Because of the lack of viable treatment options for HCC …