The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue
homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and …

SpliceAI is an open-source deep learning splicing prediction algorithm that has
demonstrated in the past few years its high ability to predict splicing defects caused by DNA …

The human body generates 10–100 billion cells every day, and the same number of cells
die to maintain homeostasis in our body. Cells infected by bacteria or viruses also die. The …

Recent advances in defining the molecular signaling pathways that regulate the
phagocytosis of apoptotic cells have improved our understanding of this complex and …

Noninflammatory clearance of apoptotic cells (ACs) is crucial to maintain self-tolerance.
Here, we have reported a role for the enzyme 12/15-lipoxygenase (12/15-LO) as a central …

Apoptotic cells are rapidly engulfed and degraded by phagocytes through efferocytosis.
Efferocytosis is a highly regulated process. It is triggered upon the activation of caspase …

Systemic lupus erythematosus is a multifactorial autoimmune disease with an as yet
unknown etiopathogenesis. It is widely thought that self-immunization in systemic lupus is …

Although the cloning and molecular characterization of MFG-E8 was first reported in the
early 90s, breakthrough on MFG-E8 research came into light when it was explored as an …

The disposal of apoptotic bodies by professional phagocytes is crucial to effective
inflammation resolution. Our ability to improve the disposal of apoptotic bodies by …

Every day billions of cells die in our bodies to eliminate those that are harmful, useless, or
senescent. The process can be divided into two steps: cell dying and cell clearance. In the …