The manner in which a mutually acceptable co-existence of biomaterials and tissues is
developed and sustained has been the focus of attention in biomaterials science for many …

Calcification plays a major role in the failure of bioprosthetic and other tissue heart valve
substitutes. Tissue valve calcification is initiated primarily within residual cells that have …

Heart valves are characterized to be highly flexible yet tough, and exhibit complex
deformation characteristics such as nonlinearity, anisotropy, and viscoelasticity, which are …

Written by more than 400 subject experts representing diverse academic and applied
domains, this multidisciplinary resource surveys the vanguard of biomaterials and …

Cardiovascular disease (CVD) is one of the leading causes of death in the Western world.
The replacement of damaged vessels and valves has been practiced since the 1950's …

Regenerative medicine technologies rely heavily on the use of well‐designed biomaterials
for therapeutic applications. The success of implantable biomaterials hinges upon the ability …

Prosthetic heart valves epitomize both the triumphant advance of cardiac surgery in its early
days and its stagnation into a retrospective, exclusive first world discipline of late. Fifty-two …

Abstract Background The α‐Gal (Galα1, 3‐Galβ1–4GlcNAc‐R) epitope is the major
xenoantigen causing hyperacute rejection of pig organs transplanted into primates. Porcine …

Background Glutaraldehyde fixation does not guarantee complete tissue biocompatibility in
current clinical bioprosthetic heart valves (BHV s). Particularly, circulating anti‐α G al human …

Glycosaminoglycans (GAGs) are important structural and functional components in native
aortic heart valves and in glutaraldehyde (Glut)-fixed bioprosthetic heart valves (BHVs) …