Fibrosis is defined as an excessive deposition of connective tissue components and can
affect virtually every organ system, including the skin, lungs, liver and kidney. Fibrotic tissue …

From the clinical standpoint, systemic sclerosis (SSc) is characterized by skin and internal
organ fibrosis, diffuse fibroproliferative vascular modifications, and autoimmunity. Clinical …

Objective T cells play a key role in the pathogenesis of early systemic sclerosis. This study
was undertaken to assess the safety and efficacy of abatacept in patients with diffuse …

Systemic autoimmune rheumatic diseases (SARDs) exhibit extensive heterogeneity in
clinical presentation, disease course, and treatment response. Therefore, precision …

Objectives Determine global skin transcriptome patterns of early diffuse systemic sclerosis
(SSc) and how they differ from later disease. Methods Skin biopsy RNA from 48 patients in …

Systemic sclerosis (SSc), also referred to as systemic scleroderma or scleroderma, is a rare,
complex immune-mediated connective tissue disease characterized by progressive skin …

Diffuse cutaneous systemic sclerosis (dcSSc) is associated with high mortality resulting from
early internal-organ involvement. Clinicians therefore tend to focus on early diagnosis and …

For many oncological conditions, the application of timely and patient-tailored targeted
therapies, or precision medicine, is a major therapeutic development that has provided …

Systemic sclerosis is the rheumatic disease with the highest individual mortality. The severity
of the disease is determined by the extent of fibrotic changes to cutaneous and internal …

With advances in information technology, the demand for using data science to enhance
healthcare and disease management is rapidly increasing. Among these technologies …