The serine/threonine kinase glycogen synthase kinase-3 (GSK-3) was initially identified and
studied in the regulation of glycogen synthesis. GSK-3 functions in a wide range of cellular …

Abstract Glycogen synthase kinase 3 (GSK-3) dysregulation plays an important role in the
pathogenesis of numerous disorders, affecting the central nervous system (CNS) …

Although glycogen synthase kinase‐3 beta (GSK‐3β) was originally named for its ability to
phosphorylate glycogen synthase and regulate glucose metabolism, this multifunctional …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …

The Wnt/β-catenin or Wnt canonical pathway controls multiple biological processes
throughout development and adult life. Growing evidences have suggested that …

Transition of acute kidney injury (AKI) to chronic kidney disease (CKD) represents an
important cause of kidney failure. However, how AKI is transformed into CKD remains …

The CCAAT/enhancer binding protein delta (CEBPD, C/EBPδ) is a transcription factor that
modulates many biological processes including cell differentiation, motility, growth arrest …

Neuroinflammatory conditions often involve dysfunction of the Blood-Brain Barrier (BBB).
Therefore, identifying molecular targets that can maintain barrier fidelity is of clinical …

The precursor nerve growth factor (ProNGF) and its receptor p75 neurotrophin receptor
(p75NTR) are upregulated in several brain diseases, including ischemic stroke. The …

Coronary artery disease and associated ischemic heart disease are prevalent disorders
worldwide. Further, systemic hypertension is common and markedly increases the risk for …