Base excision repair and cancer
SS Wallace, DL Murphy, JB Sweasy - Cancer letters, 2012 - Elsevier
Base excision repair is the system used from bacteria to man to remove the tens of
thousands of endogenous DNA damages produced daily in each human cell. Base excision …
thousands of endogenous DNA damages produced daily in each human cell. Base excision …
Mutagenicity, toxicity and repair of DNA base damage induced by oxidation
S Bjelland, E Seeberg - Mutation Research/Fundamental and Molecular …, 2003 - Elsevier
Oxidative DNA damage is a major cause of cell death and mutagenesis in all aerobic
organisms, and several new oxidative base lesions have been identified in recent years …
organisms, and several new oxidative base lesions have been identified in recent years …
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation.
Despite the important roles that G-quadruplexes play in telomere biology and gene …
Despite the important roles that G-quadruplexes play in telomere biology and gene …
Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity step
AE Vidal, ID Hickson, S Boiteux… - Nucleic acids …, 2001 - academic.oup.com
The generation of reactive oxygen species in the cell provokes, among other lesions, the
formation of 8-oxo-7, 8-dihydroguanine (8-oxoG) in DNA. Due to mispairing with adenine …
formation of 8-oxo-7, 8-dihydroguanine (8-oxoG) in DNA. Due to mispairing with adenine …
Toward a Detailed Understanding of Base Excision Repair Enzymes: Transition State and Mechanistic Analyses of N-Glycoside Hydrolysis and N-Glycoside …
PJ Berti, JAB McCann - Chemical reviews, 2006 - ACS Publications
This review focuses on the chemistry performed by base excision repair (BER) enzymes,
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
enzymes that remove nucleobases from DNA in the first step of the repair of many types of …
8-Oxo-7, 8-dihydroguanine: links to gene expression, aging, and defense against oxidative stress
The one-electron oxidation product of guanine, 8-oxo-7, 8-dihydroguanine (8-oxoG), is an
abundant lesion in genomic, mitochondrial, and telomeric DNA and RNA. It is considered to …
abundant lesion in genomic, mitochondrial, and telomeric DNA and RNA. It is considered to …
Untargeted metabolomics to characterize the urinary chemical landscape of e-cigarette users
The health and safety of using e-cigarette products (vaping) have been challenging to
assess and further regulate due to their complexity. Inhaled e-cigarette aerosols contain …
assess and further regulate due to their complexity. Inhaled e-cigarette aerosols contain …
A chemical and kinetic perspective on base excision repair of DNA
KM Schermerhorn, S Delaney - Accounts of chemical research, 2014 - ACS Publications
Conspectus Our cellular genome is continuously exposed to a wide spectrum of exogenous
and endogenous DNA damaging agents. These agents can lead to formation of an …
and endogenous DNA damaging agents. These agents can lead to formation of an …
Human DNA glycosylases involved in the repair of oxidatively damaged DNA
H Ide, M Kotera - Biological and Pharmaceutical Bulletin, 2004 - jstage.jst.go.jp
Reactive oxygen species from endogenous and environmental sources induce oxidative
damage to DNA, and hence pose an enormous threat to the genetic integrity of cells. Such …
damage to DNA, and hence pose an enormous threat to the genetic integrity of cells. Such …
Factors that influence telomeric oxidative base damage and repair by DNA glycosylase OGG1
Telomeres are nucleoprotein complexes at the ends of linear chromosomes in eukaryotes,
and are essential in preventing chromosome termini from being recognized as broken DNA …
and are essential in preventing chromosome termini from being recognized as broken DNA …