Improving physical function and mobility in a continuously expanding elderly population
emerges as a high priority of medicine today. Muscle mass, strength/power, and maximal …

Simple Summary B cells are an essential component of the immune system and develop in
the bone marrow microenvironment. B-cell development is tightly regulated by the stromal …

Adiponectin (APN), an adipokine produced by adipocytes, has been shown to have a critical
role in the pathogenesis of obesity-associated malignancies. Through its receptor …

Background Following our previous reports of an increased prevalence of insulin resistance
and adiposity among acute lymphoblastic leukemia (ALL) survivors, particularly women …

Hematopoietic stem cells (HSCs) give rise to all blood and immune cells in the body. These
rare cells reside in the hypoxic niche of the bone marrow (BM) where they are subjected to a …

Early detection of cancers is challenging for lack of specific biomarkers. Adiponectin is an
adipokine predominantly derived from adipocytes and hypoadiponectinemia has been …

Excess body weight is associated with various types of malignancies. Resistin, originally
described as an adipocyte-specific hormone modulating insulin resistance in rodents, may …

Obesity is responsible for~ 90,000 cancer deaths/year, increasing cancer incidence and
impairing its treatment. Obesity has also been shown to impact hematological malignancies …

Accumulating evidences have shown that adipokines secreted from adipocytes contributes
to tumor development, especially leptin. However, underlying mechanisms remain unclear …

Higher body mass index and adiposopathy have been associated with increased risk of
hematologic malignancies such as leukemia, multiple myeloma, myeloproliferative …