Stereodynamic strategies to induce and enrich chirality of atropisomers at a late stage
Enantiomers, where chirality arises from restricted rotation around a single bond, are
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …
atropisomers. Due to the unique nature of the origins of their chirality, synthetic strategies to …
Organocatalytic Atroposelective Dynamic Kinetic Resolution Involving Ring Manipulations
Q Shi, F Fang, DJ Cheng - Advanced Synthesis & Catalysis, 2024 - Wiley Online Library
Axially chiral architectures exist widely in natural products, biologically relevant molecules,
chiral ligands and catalysts as well as functional materials. Therefore, catalytic asymmetric …
chiral ligands and catalysts as well as functional materials. Therefore, catalytic asymmetric …
An Aqueous Three‐Component Reaction of Cyclopropanols, DABCO ⋅ (SO2)2 and Diaryliodonium salts
Y Qiu, J Yao, H Xia, C Zhu, S Ye, J Wu… - Advanced Synthesis & …, 2023 - Wiley Online Library
An additive‐and external oxidant‐free reaction of cyclopropanols, DABCO⋅(SO2) 2 and
diaryliodonium salts in aqueous phase is described. This reaction proceeds under mild …
diaryliodonium salts in aqueous phase is described. This reaction proceeds under mild …
Developing biarylhemiboronic esters for biaryl atropisomer synthesis via dynamic kinetic atroposelective Suzuki–Miyaura cross-coupling
Y Yang, C Wu, J Xing, X Dou - Journal of the American Chemical …, 2024 - ACS Publications
We herein introduce biarylhemiboronic esters as a new type of bridged biaryl reagent for
asymmetric synthesis of axially chiral biaryl structures, and the palladium-catalyzed …
asymmetric synthesis of axially chiral biaryl structures, and the palladium-catalyzed …
[HTML][HTML] Amide C–N bonds activation by A new variant of bifunctional N-heterocyclic carbene
Y Cai, Y Zhao, K Tang, H Zhang, X Mo, J Chen… - Nature …, 2024 - nature.com
We report an organocatalyst that combines a triazolium N-heterocyclic carbene (NHC) with a
squaramide as a hydrogen-bonding donor (HBD), which can effectively catalyze the …
squaramide as a hydrogen-bonding donor (HBD), which can effectively catalyze the …
Carbene-Catalyzed Direct O-Functionalization of Ketone: Atroposelective Access to Non-C2-Symmetric Binaphthyls
Disclosed here is NHC-catalyzed direct intermolecular trapping of the ketone oxygen atom
with the acyl azolium intermediate. The overall reaction is a dynamic kinetic resolution …
with the acyl azolium intermediate. The overall reaction is a dynamic kinetic resolution …
Chiral Phosphoric Acid Catalyzed Asymmetric Hydrolysis of Biaryl Oxazepines for the Synthesis of Axially Chiral Biaryl Amino Phenol Derivatives
L Wei, J Li, Y Zhao, Q Zhou, Z Wei… - Angewandte Chemie …, 2023 - Wiley Online Library
The development of catalytic asymmetric reaction with water as the reactant is challenging
due to the reactivity‐and stereoselectivity‐control issues resulted from the low nucleophilicity …
due to the reactivity‐and stereoselectivity‐control issues resulted from the low nucleophilicity …
Catalytic Atroposelective Synthesis of Axially Chiral Heterobiaryl Oxime Ethers via the One-Step Dynamic Kinetic Condensation Reaction
Q Xu, J Jia, H Fan, Z Ma, Y Wu, Y Zhang, P Su… - Organic …, 2024 - ACS Publications
The catalytic atroposelective synthesis of axially chiral heterobiaryls was first developed
through the direct one-step dynamic kinetic condensation reaction with the simple …
through the direct one-step dynamic kinetic condensation reaction with the simple …
[HTML][HTML] Atroposelective synthesis of eight-membered lactam-bridged N-arylindoles via stepwise cut-and-sew strategy
The development of efficient processes for the preparation of structurally diverse axially
chiral biaryls has been an important goal in synthetic organic chemistry and asymmetric …
chiral biaryls has been an important goal in synthetic organic chemistry and asymmetric …
[HTML][HTML] Advances in Atroposelectively De Novo Synthesis of Axially Chiral Heterobiaryl Scaffolds
X Zhang, YZ Liu, H Shao, X Ma - Molecules, 2022 - mdpi.com
Axially chiral heterobiaryl frameworks are privileged structures in many natural products,
pharmaceutically active molecules, and chiral ligands. Therefore, a variety of approaches for …
pharmaceutically active molecules, and chiral ligands. Therefore, a variety of approaches for …