Our current working model incorporates features from both the previously accepted models
of intrathymic differentiation and attempts to fit some of the more recent data regarding …

Publisher Summary This chapter discusses the multiple lymphocyte surface antigens of the
mouse. A wide range of different antigens is described, ranging from those that have a broad …

A major aim in immunology has been to understand how the immune system evokes
characteristic responses to infection, foreign tissue grafts and tumours. The current view of …

The phenotype of T cells therapeutically effective in immunotherapy of advanced Friend
virus-induced (FBL) leukemia in vivo and cytotoxic to FBL in vitro was determined. Mice …

Using monoclonal antibodies and multiparameter fluorescence analyses, we show that the
expression of Lyt-1, Lyt-2, and Lyt-3 on T cell subpopulations is more complex than was …

Monospecific cloned cytolytic T-lymphocyte lines have been created utilizing T-cell growth
factor. The clones were found to retain their cytolytic specificity after prolonged culture and …

These experiments test the hypothesis that cells carrying the Ly1+ 23-surface phenotype are
programmed exclusively for helper and not suppressive activity regardless of external …

We have shown that (a) purified T-helper cells induce cells of another T-cell set-, expressing
the Ly123+ Qa1+ surface phenotype, to exert potent suppressive activity,(b) this TT …

Purified T lymphocytes mediate a wide variety of immunologic functions. These cells can
generate cytotoxic responses to alloantigens (Cerottini and Brunner, 1974; Cantor et al …

CBA/N mice have an X-linked B-cell maturation defect which is reflected in part in an
absence or dysfunction of a subclass of mature B cells. We have immunized the defective …