Developmental signaling pathways control a vast array of biological processes during
embryogenesis and in adult life. The WNT pathway was discovered simultaneously in …

The systemic spread of tumor cells is the ultimate cause of the majority of deaths from
cancer, yet few successful therapeutic strategies have emerged to specifically target …

Wnt signaling plays crucial roles in development and tissue homeostasis, and its
dysregulation leads to various diseases, notably cancer. Wnt/β-catenin signaling is initiated …

Metastasis significantly reduces the survival rate of osteosarcoma (OS) patients. Therefore,
identification of novel targets remains extremely important to prevent metastasis and treat …

Alzheimer's disease (AD) has been a major health issue for more than one century since it
was first reported in 1906. As one of the most common neurodegenerative diseases, AD is …

Upon binding to the canonical WNT glycoproteins, Frizzled family receptors (FZDs) and low-
density lipoprotein receptor-related protein 5/6 (LRP5/6) undergo a series of polymerizations …

The WNT/β-catenin signalling pathway is a rich and complex network of cellular proteins that
orchestrates diverse short-range cell-to-cell communication in metazoans and is essential …

Abstract Background and Aims Anti-hypertensive agents are one of the most frequently used
drugs worldwide. However, no blood pressure–lowering strategy is superior to placebo with …

Background: Myocardial infarction is one of the leading causes of morbidity and mortality
worldwide, triggering irreversible myocardial cell damage and heart failure. The role of low …

The low‐density lipoprotein receptor‐related protein 6 (LRP6) is an essential Wnt co‐
receptor of the Wnt/β‐catenin signaling pathway. Although studies have shown an increased …