The respiratory syncytial virus vaccine landscape: lessons from the graveyard and promising candidates

NI Mazur, D Higgins, MC Nunes, JA Melero… - The Lancet Infectious …, 2018 - thelancet.com
The global burden of disease caused by respiratory syncytial virus (RSV) is increasingly
recognised, not only in infants, but also in older adults (aged≥ 65 years). Advances in …

Respiratory syncytial virus infection in adults

HH Nam, MG Ison - bmj, 2019 - bmj.com
Human respiratory syncytial virus (RSV) belongs to the recently defined Pneumoviridae
family, Orthopneumovirus genus. It is a negative sense, single stranded RNA virus that …

Development of mRNA vaccines against respiratory syncytial virus (RSV)

X Qiu, S Xu, Y Lu, Z Luo, Y Yan, C Wang, J Ji - Cytokine & Growth Factor …, 2022 - Elsevier
Respiratory syncytial virus (RSV) is a single-stranded negative-sense RNA virus that is the
primary etiologic pathogen of bronchitis and pneumonia in infants and the elderly. Currently …

Structure-based vaccine antigen design

BS Graham, MSA Gilman… - Annual review of …, 2019 - annualreviews.org
Enabled by new approaches for rapid identification and selection of human monoclonal
antibodies, atomic-level structural information for viral surface proteins, and capacity for …

Antibody effector functions are associated with protection from respiratory syncytial virus

YC Bartsch, D Cizmeci, J Kang, T Zohar, S Periasamy… - Cell, 2022 - cell.com
Respiratory syncytial virus (RSV) infection is a major cause of severe lower respiratory tract
infection and death in young infants and the elderly. With no effective prophylactic treatment …

[HTML][HTML] Vaccines based on replication incompetent Ad26 viral vectors: Standardized template with key considerations for a risk/benefit assessment

J Custers, D Kim, M Leyssen, M Gurwith, F Tomaka… - Vaccine, 2021 - Elsevier
Replication-incompetent adenoviral vectors have been under investigation as a platform to
carry a variety of transgenes, and express them as a basis for vaccine development. A …

[HTML][HTML] Respiratory syncytial virus: from pathogenesis to potential therapeutic strategies

Z Shang, S Tan, D Ma - International Journal of Biological Sciences, 2021 - ncbi.nlm.nih.gov
Respiratory syncytial virus (RSV) is one of the most important viral pathogens causing
respiratory tract infection in infants, the elderly and people with poor immune function, which …

Vaccine development for respiratory syncytial virus

BS Graham - Current opinion in Virology, 2017 - Elsevier
Highlights•RSV is an important cause of lower respiratory tract infection and disease at the
extremes of age.•The RSV fusion (F) glycoprotein is the major target for virus neutralizing …

Respiratory syncytial virus: the influence of serotype and genotype variability on clinical course of infection

S Vandini, C Biagi, M Lanari - International journal of molecular sciences, 2017 - mdpi.com
Respiratory syncytial virus (RSV) belongs to the recently defined Pneumoviridae family,
Orthopneumovirus genus. It is the leading cause of acute bronchiolitis and one of the most …

Ad26. COV2. S protects Syrian hamsters against G614 spike variant SARS-CoV-2 and does not enhance respiratory disease

JEM van Der Lubbe, SK Rosendahl Huber, A Vijayan… - npj Vaccines, 2021 - nature.com
Previously we have shown that a single dose of recombinant adenovirus serotype 26 (Ad26)
vaccine expressing a prefusion stabilized SARS-CoV-2 spike antigen (Ad26. COV2. S) is …