[HTML][HTML] Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
Determinants of enhancer and promoter activities of regulatory elements
R Andersson, A Sandelin - Nature Reviews Genetics, 2020 - nature.com
The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …
transcription within a cell. Although diverse methodologies have been developed to identify …
Roles and regulation of histone methylation in animal development
A Jambhekar, A Dhall, Y Shi - Nature reviews Molecular cell biology, 2019 - nature.com
Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …
arginine residues, and it can be governed by multiple positive and negative regulators, even …
Comprehensive catalog of currently documented histone modifications
Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …
proteomics have identified a large number of novel histone posttranslational modifications …
Histone methylation: a dynamic mark in health, disease and inheritance
EL Greer, Y Shi - Nature Reviews Genetics, 2012 - nature.com
Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …
One‐carbon metabolism and epigenetics: understanding the specificity
SJ Mentch, JW Locasale - Annals of the New York Academy of …, 2016 - Wiley Online Library
One‐carbon metabolism is a metabolic network that integrates nutrient status from the
environment to yield multiple biological functions. The folate and methionine cycles …
environment to yield multiple biological functions. The folate and methionine cycles …
Is H3K4me3 instructive for transcription activation?
Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …
modification at the transcription start site of active genes in eukaryotes from yeast to man …
Perceiving the epigenetic landscape through histone readers
CA Musselman, ME Lalonde, J Côté… - Nature structural & …, 2012 - nature.com
Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …
[HTML][HTML] High-resolution profiling of histone methylations in the human genome
Histone modifications are implicated in influencing gene expression. We have generated
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …
A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism
MA Herman, OD Peroni, J Villoria, MR Schön… - Nature, 2012 - nature.com
The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to
shorten lifespan. Impaired insulin action in peripheral tissues is a major pathogenic factor …
shorten lifespan. Impaired insulin action in peripheral tissues is a major pathogenic factor …