Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

The proper activities of enhancers and gene promoters are essential for coordinated
transcription within a cell. Although diverse methodologies have been developed to identify …

Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Modern techniques in molecular biology, genomics, and mass spectrometry–based
proteomics have identified a large number of novel histone posttranslational modifications …

Organisms require an appropriate balance of stability and reversibility in gene expression
programmes to maintain cell identity or to enable responses to stimuli; epigenetic regulation …

One‐carbon metabolism is a metabolic network that integrates nutrient status from the
environment to yield multiple biological functions. The folate and methionine cycles …

Tri‐methylation of lysine 4 on histone H3 (H3K4me3) is a near‐universal chromatin
modification at the transcription start site of active genes in eukaryotes from yeast to man …

Post-translational modifications (PTMs) of histones provide a fine-tuned mechanism for
regulating chromatin structure and dynamics. PTMs can alter direct interactions between …

Histone modifications are implicated in influencing gene expression. We have generated
high-resolution maps for the genome-wide distribution of 20 histone lysine and arginine …

The prevalence of obesity and type 2 diabetes is increasing worldwide and threatens to
shorten lifespan. Impaired insulin action in peripheral tissues is a major pathogenic factor …