Plasmids, a molecular cornerstone of antimicrobial resistance in the One Health era

S Castañeda-Barba, EM Top, T Stalder - Nature Reviews Microbiology, 2024 - nature.com
Antimicrobial resistance (AMR) poses a substantial threat to human health. The widespread
prevalence of AMR is, in part, due to the horizontal transfer of antibiotic resistance genes …

[HTML][HTML] Antibiotic resistance in the environment

DG Larsson, CF Flach - Nature Reviews Microbiology, 2022 - nature.com
Antibiotic resistance is a global health challenge, involving the transfer of bacteria and
genes between humans, animals and the environment. Although multiple barriers restrict the …

An omics-based framework for assessing the health risk of antimicrobial resistance genes

AN Zhang, JM Gaston, CL Dai, S Zhao, M Poyet… - Nature …, 2021 - nature.com
Antibiotic resistance genes (ARGs) are widespread among bacteria. However, not all ARGs
pose serious threats to public health, highlighting the importance of identifying those that are …

Examining horizontal gene transfer in microbial communities

IL Brito - Nature Reviews Microbiology, 2021 - nature.com
Bacteria acquire novel DNA through horizontal gene transfer (HGT), a process that enables
an organism to rapidly adapt to changing environmental conditions, provides a competitive …

Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment

Y He, Q Yuan, J Mathieu, L Stadler, N Senehi, R Sun… - NPJ Clean …, 2020 - nature.com
Antibiotics are widely used in animal husbandry, and various types of antibiotic resistance
genes (ARGs) are frequently detected in livestock waste around the world. Conventional …

Antibiotic-resistance genes in waste water

A Karkman, TT Do, F Walsh, MPJ Virta - Trends in microbiology, 2018 - cell.com
Waste water and waste water treatment plants can act as reservoirs and environmental
suppliers of antibiotic resistance. They have also been proposed to be hotspots for …

Horizontal transfer of antibiotic resistance genes in the human gut microbiome

RS McInnes, GE McCallum, LE Lamberte… - Current opinion in …, 2020 - Elsevier
Highlights•The human gut microbiome harbours antibiotic resistance genes ('the
resistome').•Antibiotic resistance genes can spread in the gut microbiome through horizontal …

Uncultivated microbes in need of their own taxonomy

KT Konstantinidis, R Rosselló-Móra… - The ISME journal, 2017 - academic.oup.com
The great majority of microbial species remains uncultured, severely limiting their taxonomic
characterization and thus communication among scientists. Although Candidatus was …

[HTML][HTML] Evolution of plasmid-mediated antibiotic resistance in the clinical context

A San Millan - Trends in microbiology, 2018 - cell.com
Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply
increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance …

Antibiotic resistance in wastewater treatment plants: Tackling the black box

CM Manaia, J Rocha, N Scaccia, R Marano… - Environment …, 2018 - Elsevier
Wastewater is among the most important reservoirs of antibiotic resistance in urban
environments. The abundance of carbon sources and other nutrients, a variety of possible …