Every cell must satisfy basic requirements for nutrient sensing, utilization and recycling
through macromolecular breakdown to coordinate programmes for growth, repair and stress …

Sarcopenia is a loss of muscle mass and function in the elderly that reduces mobility,
diminishes quality of life, and can lead to fall-related injuries, which require costly …

Inhibition of the protein kinase mechanistic target of rapamycin (mTOR) with the Food and
Drug Administration (FDA)-approved therapeutic rapamycin promotes health and longevity …

With human median lifespan extending into the 80s in many developed countries, the
societal burden of age-related muscle loss (sarcopenia) is increasing. mTORC1 promotes …

From the dawn of civilization, humanity has dreamed of immortality. So why didn't the
discovery of the anti-aging properties of mTOR inhibitors change the world forever? I will …

Sarcopenia has been defined as a progressive decline of skeletal muscle mass, strength,
and functions in elderly people. It is accompanied by physical frailty, functional disability …

There is a lack of pharmacological interventions available for sarcopenia, a progressive age-
associated loss of muscle mass, leading to a decline in mobility and quality of life. We found …

Highlights•The function of the autophagy/lysosome system declines during skeletal muscle
aging.•Boosting basal autophagy protects from sarcopenia.•Autophagy inhibition impedes …

Sarcopenia is a well-known geriatric syndrome that has been endorsed over the years as a
biomarker allowing for the discrimination, at a clinical level, of biological from chronological …

Beside inherited muscle diseases many catabolic conditions such as insulin resistance,
malnutrition, cancer growth, aging, infections, chronic inflammatory status, inactivity, obesity …