CYP2J2-mediated metabolism of arachidonic acid in heart: A review of its kinetics, inhibition and role in heart rhythm control
JWH Leow, ECY Chan - Pharmacology & Therapeutics, 2024 - Elsevier
Abstract Cytochrome P450 2 J2 (CYP2J2) is primarily expressed extrahepatically and is the
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …
predominant epoxygenase in human cardiac tissues. This highlights its key role in the …
[HTML][HTML] Investigating the relevance of CYP2J2 inhibition for drugs known to cause intermediate to high risk torsades de pointes
JWH Leow, Y Gu, ECY Chan - European Journal of Pharmaceutical …, 2023 - Elsevier
Abstract Cardiac cytochrome P450 2J2 (CYP2J2) metabolizes endogenous polyunsaturated
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …
fatty acid, arachidonic acid (AA), to bioactive regioisomeric epoxyeicosatrienoic acid (EET) …
Atypical kinetics of cytochrome P450 2J2: epoxidation of arachidonic acid and reversible inhibition by xenobiotic inhibitors
Extrahepatic CYP2J2 metabolism of arachidonic acid (AA) to bioactive regioisomeric
epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological …
epoxyeicosatrienoic acids (EETs) is implicated in both physiological and pathological …