Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …

The bromodomain and extraterminal (BET) protein Brd4 recruits transcriptional regulatory
complexes to acetylated chromatin. While Brd4 is considered to be a general transcriptional …

The development of effective pharmacological inhibitors of multidomain scaffold proteins,
notably transcription factors, is a particularly challenging problem. In part, this is because …

The Bromo-and Extra-Terminal (BET) proteins BRD2, BRD3, and BRD4 play important roles
in transcriptional regulation, epigenetics, and cancer and are the targets of pan-BET …

Processive elongation of RNA Polymerase II from a proximal promoter paused state is a rate-
limiting event in human gene control. A small number of regulatory factors influence …

Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease
for which there is no targeted therapy,,. BET bromodomain inhibitors, which have shown …

Proinflammatory stimuli elicit rapid transcriptional responses via transduced signals to
master regulatory transcription factors. To explore the role of chromatin-dependent signal …

The intestinal microbiome releases a plethora of small molecules. Here, we show that the
Ruminococcaceae metabolite isoamylamine (IAA) is enriched in aged mice and elderly …

Transcriptional deregulation is one of the core tenets of cancer biology and is underpinned
by alterations in both protein-coding genes and noncoding regulatory elements. Large …

Natural products and synthetic small molecules can be used to perturb, dissect and
manipulate biological processes, thereby providing the basis for drug development. Over the …