Sepsis or serious infection within the first 4 weeks of life kills more than 1 million newborns
globally every year. 1 The attack rate for neonatal sepsis is variable (from< 1% to> 35% of …

Persistence of pulmonary hypertension leading to respiratory failure in the neonate has
been recognized for 40 years since its original description by Gersony and colleagues 1 in …

Importance The association between selective serotonin reuptake inhibitor (SSRI)
antidepressant use during pregnancy and risk of persistent pulmonary hypertension of the …

Background Persistent pulmonary hypertension of the newborn (PPHN) is associated with
substantial infant mortality and morbidity. A previous cohort study suggested a possible …

Objective To assess whether maternal use of selective serotonin reuptake inhibitors (SSRIs)
increases the risk of persistent pulmonary hypertension in the newborn, and whether such …

OBJECTIVE: To evaluate the safety of intravenous (IV) sildenafil, an inhibitor of cyclic
guanosine monophosphate–specific phosphodiesterase, in treating near-term and term …

OBJECTIVE. Persistent pulmonary hypertension of the newborn, a clinical syndrome that
results from the failure of the normal fetal-to-neonatal circulatory transition, is associated with …

The main cause of pulmonary hypertension in newborn babies results from the failure of the
pulmonary circulation to dilate at birth, termed 'persistent pulmonary hypertension of the …

OBJECTIVE: Persistent pulmonary hypertension of the newborn (PPHN) is a clinical
syndrome of late-preterm and full-term infants associated with failure of the normal fetal-to …

In the pulmonary vasculature, cGMP concentrations are regulated in part by a cGMP-
dependent phosphodiesterase (PDE), PDE5. Infants with persistent pulmonary hypertension …