Cancer is a multifactorial disease that is responsible for 10 million deaths per year. The intra-
and inter-heterogeneity of malignant tumors make it difficult to develop single targeted …

Bioprinting, within the emerging field of biofabrication, aims at the fabrication of functional
biomimetic constructs. Different 3D bioprinting techniques have been adapted to bioprint cell …

Abstract In 2013, the “biofabrication window” was introduced to reflect the processing
challenge for the fields of biofabrication and bioprinting. At that time, the lack of printable …

Building tissues from scratch to explore entirely new cell configurations could revolutionize
fundamental understanding in biology. Bioprinting is an emerging technology to do this …

Many drugs show promising results in laboratory research but eventually fail clinical trials.
We hypothesize that one main reason for this translational gap is that current cancer models …

The cancer microenvironment is known for its complexity, both in its content as well as its
dynamic nature, which is difficult to study using two-dimensional (2D) cell culture models …

Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

Effort invested in the development of new drugs often fails to be translated into meaningful
clinical benefits for patients with cancer. The development of more effective anticancer …

Malignant brain tumours are complex ecosystems containing neoplastic and stromal
components that generate adaptive and evolutionarily driven aberrant tissues in the central …

Brain tumors are dynamic complex ecosystems with multiple cell types. To model the brain
tumor microenvironment in a reproducible and scalable system, we developed a rapid three …