Fibrosis is a process characterized by an excessive accumulation of the extracellular matrix
as a response to different types of tissue injuries, which leads to organ dysfunction. The …

Despite renin-angiotensin-aldosterone system blockade, which retards progression of CKD
by reducing proteinuria, many patients with CKD have residual proteinuria, an independent …

Background Despite treatment with renin–angiotensin–aldosterone system (RAAS)
inhibitors, patients with diabetes have increased risk of progressive renal failure that …

Vitamin D regulates the renin-angiotensin system (RAS) in experimental animals, but
corresponding human data are limited. We examined the relation between plasma 25 …

Recent studies implicate Wnt/β-catenin signaling in podocyte dysfunction. Because vitamin
D analogs can inhibit β-catenin in other tissues, we tested whether the vitamin D analog …

BACKGROUND Diabetic nephropathy is a major risk of end-stage kidney disease. Many
complex factors relate to the progression of diabetic nephropathy. Using nonobese type 2 …

Inflammation is a pathologic feature of a variety of chronic kidney diseases. Several lines of
evidence suggest a potential anti-inflammatory role for vitamin D in chronic kidney disease …

Analogs of vitamin D attenuate renal injury in several models of kidney disease, but the
mechanism underlying this renoprotective effect is unknown. To address the role of the …

The renal renin–angiotensin system plays a major role in determining the rate of chronic
renal disease progression. Treatment with activators of the vitamin D receptor retards the …

Local inflammation is thought to contribute to the progression of diabetic nephropathy. The
vitamin D receptor (VDR) activator paricalcitol has an antiproteinuric effect in human diabetic …