Background: Recent studies have identified the combination of vancomycin with piperacillin-
tazobactam (VPT) to be associated with increased nephrotoxicity. Multiple, large cohort …

Purpose Although dozens of studies have associated vancomycin+ piperacillin–tazobactam
with increased acute kidney injury (AKI) risk, it is unclear whether the association represents …

Importance Cefepime and piperacillin-tazobactam are commonly administered to
hospitalized adults for empirical treatment of infection. Although piperacillin-tazobactam has …

Drug-induced nephrotoxicity accounts for up to 60% of cases of acute kidney injury (AKI) in
hospitalized patients and is associated with increased morbidity and mortality in both adults …

Clinical studies have reported additive nephrotoxicity associated with the combination of
vancomycin (VAN) and piperacillin-tazobactam (TZP). This study assessed differences in …

The rate of eradication of periprosthetic joint infection (PJI) caused by methicillin-resistant
Staphylococcus aureus (MRSA) is still not satisfactory with systemic vancomycin …

Background Piperacillin/tazobactam, a commonly used antibiotic, is associated with acute
kidney injury (AKI). The relationship between piperacillin concentrations and AKI remains …

Among patients with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia from a
prospective randomized clinical trial, acute kidney injury (AKI) rates increased with …

Background Vancomycin (VAN)-associated acute kidney injury (AKI) is increased when VAN
is combined with certain beta-lactams (BLs) such as piperacillin-tazobactam (TZP) but has …

The recent understanding that hydrophobic β-lactams have greater affinity for organic anion
transporter-3 (OAT-3) of the proximal renal tubule could provide valuable insights for …