The mechanisms by which the pigment melanin is transferred from melanocytes and
processed within keratinocytes to achieve skin pigmentation remain ill-characterized …

Microphthalmia-associated transcription factor (MITF) is an important regulator of
melanogenesis and melanocyte development. Although it has been studied extensively in …

Human skin and hair pigmentation play important roles in social behavior but also in
photoprotection from the harmful effects of ultraviolet light. The main pigments in mammalian …

Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin,
which is produced by epidermal melanocytes and transferred to surrounding keratinocytes …

Skin cancers are among the most common cancers worldwide and are increasingly
prevalent. Cutaneous melanoma (CM) is characterized by the malignant transformation of …

Melanosomes are specialized intracellular organelles that produce and store melanin
pigments in melanocytes, which are present in several mammalian tissues and organs …

A novel series of thirty coumarin derivatives (4a∼ r, 5a∼ l) constituted by coumarin and
cinnamic acid/benzoic acid through oxime linkage were synthesized and evaluated for their …

The epidermis is located in the outermost layer of the living body and is the place where
external stimuli such as ultraviolet rays and microorganisms first come into contact …

When host cells are exposed to foreign particles, dead cells, or cell hazards, a sophisticated
process called phagocytosis begins. During this process, macrophages, dendritic cells, and …

Lysosomes are dynamic organelles, capable of undergoing exocytosis. This process is
crucial for several cellular functions, namely plasma membrane repair. Nevertheless, the …