Significance: A vast amount of circumstantial evidence implicates high energy oxidants and
oxidative stress as mediators of secondary damage associated with traumatic brain injury …

NO and its derivatives can have multiple effects, which impact on neuronal death in different
ways. High levels of NO induces energy depletion-induced necrosis, due to:(i) rapid …

Ferroptotic death is the penalty for losing control over three processes—iron metabolism,
lipid peroxidation and thiol regulation—that are common in the pro-inflammatory …

We investigated oxidative stress in human postmortem frontal cortexfrom individuals
characterized as mild cognitive impairment (n= 8), mild/moderate Alzheimer disease (n= 4) …

The mitochondrion is vital for many metabolic pathways in the cell, contributing all or
important constituent enzymes for diverse functions such as β-oxidation of fatty acids, the …

Traumatic brain injury (TBI) is a major healthcare concern, constituting a major cause of
death and disability throughout the world. Among the factors leading to TBI outcome are …

Traumatic brain injury is a leading cause of morbidity and death in both industrialized and
developing countries. To date, there is no targeted pharmacological treatment that effectively …

Covalent amino acid modification significantly expands protein functional capability in
regulating biological processes. Tyrosine residues can undergo phosphorylation, sulfation …

Oxidative stress, an imbalance between oxidants and antioxidants, contributes to the
pathogenesis of traumatic brain injury (TBI). Oxidative neurodegeneration is a key mediator …

Nitric oxide (NO) has been known for many years to bind to cytochrome C oxidase, the
terminal acceptor in the mitochondrial electron transport chain, in competition with oxygen …