Conspectus Transition metal hydride catalyzed functionalization of remote and proximal
olefins has many advantages over conventional cross-coupling reactions. It avoids the …

Compounds rich in sp3-hybridized carbons are desirable in drug discovery. Nickel-
catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these …

The key objectives of medicinal chemistry are to efficiently design and synthesize bioactive
compounds that have the potential to become safe and efficacious drugs. Most medicinal …

Electrochemistry grants direct access to reactive intermediates (radicals and ions) in a
controlled fashion toward selective organic transformations. This feature has been …

Hydrometallation of alkenes and alkynes provides a straightforward route to access alkyl‐or
alkenyl‐metal reagents, which have a wide range of applications in organic transformations …

This paper reviewed the recent research progress of organic reactions catalyzed by four
typical earth-abundant and 3d metal catalysts: Mn, Fe, Co, and Ni complexes and mainly …

Site-and enantio-selective alkyl–alkyl bond formation is privileged in the retrosynthetic
analysis due to the universality of sp3-hybridized carbon atoms in organic molecules …

Carbon–carbon bonds, including those between sp 3-hybridized carbon atoms (alkyl–alkyl
bonds), typically comprise much of the framework of organic molecules. In the case of sp 3 …

To increase the reliability and success rate of drug discovery, efforts have been made to
increase the C (sp 3) fraction and avoid flat molecules. sp 3-Rich enantiopure amines are …

Abstract Enantioselective C (sp 3)–C (sp 3) coupling substantially impacts organic synthesis
but remains challenging. Cobalt has played an important role in the development of …