[HTML][HTML] Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024)

X Mo, DP Rao, K Kaur, R Hassan, AS Abdel-Samea… - Molecules, 2024 - mdpi.com
Indole derivatives have become an important class of compounds in medicinal chemistry,
recognized for their wide-ranging biological activities and therapeutic potential. This review …

Anticancer agents incorporating the N‐acylhydrazone scaffold: Progress from 2017 to present

AE Kassab - Archiv der Pharmazie, 2023 - Wiley Online Library
The N‐acylhydrazone motif has been shown to be particularly adaptable and promising in
the area of medicinal chemistry and drug development, due to its significant biological and …

New 2H‐Chromene‐Based Hydrazone Derivatives as Promising Anti‐Breast Cancer Agents: Efficient Synthesis, Spectral Characterization, Molecular Docking, and …

B Shankar Panda, B Samanta… - …, 2024 - Wiley Online Library
A new series of 2H‐chromene‐based hydrazones (10 a–w, 12 a–d, and 14 a–d) were
efficiently synthesized by the reaction of substituted 2H‐chromene aldehydes (8 a–w) with …

Investigation of Antimicrobial, Anti‐Quorum Sensing, and Cytotoxic Activities of Flavonoids Isolated from Pulicaria armena Boiss. & Kotschy ex Boiss. (Asteraceae)

Y Başpınar, P Gürbüz, Ş Dilem Doğan… - Chemistry & …, 2023 - Wiley Online Library
This is the first report on the separation and biological assessment of all metabolites derived
from Pulicaria armena (Asteraceae) which is an endemic species narrowly distributed in the …

In silico Analysis of Natural Products from Brazilian Biodiversity in COVID-19 Treatment: NuBBE Database against SARS-CoV-2 Papain-Like Protease

CFAR Cheohen, MEA Esteves, VMS Gomes… - Journal of the Brazilian …, 2024 - SciELO Brasil
Coronavirus disease (COVID-19) pandemic has infected 630 million people and led to 6.59
million deaths worldwide since its outbreak. To control COVID-19 advance, finding new …

Experimental and Theoretical Study on Hydrazine Derivatives: Structural, Electronic, and Reactivity Analysis

I Rafiq, AEL Assyry, SA Hassan… - Moroccan Journal of …, 2025 - revues.imist.ma
This study combines both experimental and theoretical methods comprehensively to explore
the detailed molecular properties of a series of hydrazine derivatives:(E)-1-(2, 4 …

SYNTHESIS, CHARACTERIZATION AND X-RAY CRYSTAL STRUCTURE OF N′-(3,5-DIFLUORO-2- HYDROXYBENZYLIDENE)-4-METHYLBENZOHYDRAZIDE …

M Li, XY Qiu, ZX Zheng, YJ Wu - Journal of Structural Chemistry, 2023 - Springer
A new aroylhydrazone compound N′-(3, 5-difluoro-2-hydroxybenzylidene)-4-
methylbenzohydrazide (H2L) was prepared. The compound was characterized by IR, UV …