Background Knee osteoarthritis (OA) is a chronic progressive disease that imparts a
substantial socioeconomic burden to society and healthcare systems. The prevalence of …

Optimal management of knee osteoarthritis (KOA) should include, where possible,
modification of risk factors through targeted interventions. The objectives of the present …

Knee osteoarthritis (KOA) is a common chronic debilitating disease with an estimated
prevalence of 23.9% in the general adult population. The condition is characterised by joint …

Aims The PREVIEW lifestyle intervention study (ClinicalTrials. gov Identifier: NCT01777893)
is, to date, the largest, multinational study concerning prevention of type‐2 diabetes. We …

Objective To test the effectiveness and safety of a total diet replacement (TDR) programme
for routine treatment of obesity in a primary care setting. Design Pragmatic, two arm, parallel …

Background The existence of metabolic adaptation, at the level of resting metabolic rate
(RMR), remains highly controversial, likely due to lack of standardization of participants' …

Objective To assess the effectiveness of weight-loss interventions on pain and disability in
people with knee and hip osteoarthritis (OA) and spinal pain. Design Intervention systematic …

Worldwide obesity rates remain at a rise, and to treat obesity is at the top of the global public
health agenda. In 2013, the AHA/ACC/TOS obesity management guidelines were published …

Existing clinical guidelines recommend weight loss for adults with knee osteoarthritis and
obesity, but the supporting evidence to date remains inadequate. There is also no pooled …

This study investigated the effects of home-based nutritional and telemedicine-based
resistance exercise interventions on improving body composition, blood biochemistry, and …