N-Glycans are covalently attached to protein at asparagine (Asn) residues by an N-
glycosidic bond. Although diverse sugars are attached to Asn in prokaryotes (Chapters 21 …

A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …

Protein glycosylation represents a nearly ubiquitous post-translational modification, and
altered glycosylation can result in clinically significant pathological consequences. Here we …

Asparagine-linked glycosylation (N-glycosylation) of proteins in the cancer secretome has
been gaining increasing attention as a potential biomarker for cancer detection and …

Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca 2+
sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai …

Intestinal ischemia-reperfusion (IR) injury is associated with high mortality rates, which have
not improved in the past decades despite advanced insight in its pathophysiology using in …

To maximize therapeutic effects and minimize unwanted effects, the interest in drug targeting
to the endoplasmic reticulum (ER) or Golgi apparatus (GA) has been recently growing …

Sperm acrosomal membrane proteins, such as Izumo sperm–egg fusion 1 (IZUMO1) and
sperm acrosome-associated 6 (SPACA6), play essential roles in mammalian gamete …

Abstract Cyclin M (CNNM1-4) proteins maintain cellular and body magnesium (Mg2+)
homeostasis. Using various biochemical approaches, we have identified members of the …

Background Cutaneous squamous cell carcinoma (cSCC) is one of the most common
cancers capable of metastasizing. Proteomic analysis of cSCCs can provide insight into the …