Chronic fatigue syndrome (CFS) is a common and disabling problem; although most likely of
biopsychosocial origin, the nature of the pathophysiological components remains unclear …

Objectives Functional somatic syndromes are common and disabling conditions that all
include chronic pain, and which may be related to central nervous system sensitisation …

Background Reports of mild hypocortisolism in chronic fatigue syndrome led us to postulate
that low-dose hydrocortisone therapy may be an effective treatment. Methods In a …

Many studies of patients with long-standing chronic fatigue syndrome (CFS) have found
alterations to the hypothalamo–pituitary–adrenal (HPA) axis, including mild hypocortisolism …

The circadian rhythmicity of endogenous metabolic and hormonal processes is controlled by
a complex system of central and peripheral pacemakers, influenced by exogenous factors …

Background. Disturbance of the HPA axis may be important in the pathophysiology of
chronic fatigue syndrome (CFS) and fibromyalgia. Symptoms may be due to:(1) low …

Psychobiological investigations on the hypothalamus–pituitary–adrenal (HPA) axis depend
on markers that adequately describe the activity of this system. There is evidence that the …

Context.—Chronic fatigue syndrome (CFS) is associated with a dysregulated hypothalamic–
pituitary adrenal axis and hypocortisolemia. Objective.—To evaluate the efficacy and safety …

OBJECTIVE: It has been suggested that a hypofunctional hypothalamic–pituitary–adrenal
(HPA) axis in chronic fatigue syndrome could result in an exaggerated release of pro …

These neuroendocrine studies were part of a series of studies testing the hypotheses that 1)
there may be reduced activity of the hypothalamic-pituitary-adrenal axis in chronic fatigue …