Similar to many other biological molecules, RNA is vulnerable to chemical insults from
endogenous and exogenous sources. Noxious agents such as reactive oxygen species or …

Ribosomes translate genetic information into polypeptides in several basic steps: initiation,
elongation, termination and recycling. When ribosomes are arrested during elongation or …

Aberrantly slow translation elicits quality control pathways initiated by the ubiquitin ligase
ZNF598. How ZNF598 discriminates physiologic from pathologic translation complexes and …

Ribosome stalling triggers quality control pathways targeting the mRNA (NGD: no‐go decay)
and the nascent polypeptide (RQC: ribosome‐associated quality control). RQC requires …

Translation arrest by polybasic sequences induces ribosome stalling, and the arrest product
is degraded by the ribosome-mediated quality control (RQC) system. Here we report that …

No-go decay (NGD) is a eukaryotic quality control mechanism that evolved to cope with
translational arrests. The process is characterized by an endonucleolytic cleavage near the …

Diverse cellular stressors have been observed to trigger site-specific ubiquitination on
several ribosomal proteins. However, the ubiquitin ligases, biochemical consequences, and …

Cryptic polyadenylation within coding sequences (CDS) triggers ribosome-associated
quality control (RQC), followed by degradation of the aberrant mRNA and polypeptide …

Cells of all organisms survey problems during translation elongation, which may happen as
a consequence of mRNA aberrations, inefficient decoding, or other sources. In eukaryotes …

Ribosome-associated quality control (RQC) pathways protect cells from toxicity caused by
incomplete protein products resulting from translation of damaged or problematic mRNAs …