The interferon (IFN) system is an extremely powerful antiviral response that is capable of
controlling most, if not all, virus infections in the absence of adaptive immunity. However …

The action of interferons (IFNs) on virus-infected cells and surrounding tissues elicits an
antiviral state that is characterized by the expression and antiviral activity of IFN-stimulated …

Innate sensing of microbial components is well documented to occur at many cellular sites,
including at the cell surface, in the cytosol, and in intracellular vesicles, but there is limited …

Human cytomegalovirus (CMV) is a ubiquitous opportunistic pathogen that causes
significant morbidity and mortality in immuncompromised people. An understanding of how …

The Ebola virus VP35 protein was previously found to act as an interferon (IFN) antagonist
which could complement growth of influenza delNS1 virus, a mutant influenza virus lacking …

The establishment of an intracellular antiviral state is the defining activity of interferons
(IFNs) as well as the property that permitted their discovery. Several pathways have been …

In the struggle between virus and host, control over the cell's death machinery is crucial for
survival. Viruses are obligatory intracellular parasites and, as such, must modulate apoptotic …

The influenza A virus NS1 protein (NS1A protein) binds and inhibits the function of the 30-
kDa subunit of CPSF, a cellular factor that is required for the 3′-end processing of cellular …

Human cytomegalovirus (HCMV) is a member of the betaherpesvirus family that, unlike
other herpesviruses, triggers a strong innate immune response in infected cells that includes …

Virus infection induces a rapid cellular response in cells characterized by the induction of
interferon. While interferon itself does not induce an antiviral response, it activates a number …