Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional
programs. These dysregulated programs can cause cancer cells to become highly …

Loss of cellular homeostasis during aging results in altered tissue functions and leads to a
general decline in fitness and, ultimately, death. As animals age, the control of gene …

The human and mouse genomes contain instructions that specify RNAs and proteins and
govern the timing, magnitude, and cellular context of their production. To better delineate …

Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a
highly aggressive acute leukaemia associated with poor clinical outcome. The preferential …

Synovial sarcoma tumours contain a characteristic fusion protein, SS18-SSX, which drives
disease development. Targeting oncogenic fusion proteins presents an attractive …

Hematological malignancies comprise a diverse set of lymphoid and myeloid neoplasms in
which normal hematopoiesis has gone awry and together account for∼ 10% of all new …

The epigenome is a key determinant of transcriptional output. Perturbations within the
epigenome are thought to be a key feature of many, perhaps all cancers, and it is now clear …

Understanding the mechanism of small molecules is a critical challenge in chemical biology
and drug discovery. Medicinal chemistry is essential for elucidating drug mechanism …

Acute myeloid leukemia (AML) was one of the first cancers to be sequenced at the level of
the whole genome. Molecular profiling of AML through targeted sequencing panels and …

Epigenetic regulators are recurrently mutated and aberrantly expressed in acute myeloid
leukemia (AML). Targeted therapies designed to inhibit these chromatin-modifying enzymes …