[HTML][HTML] Mechanisms and disease consequences of nonalcoholic fatty liver disease

R Loomba, SL Friedman, GI Shulman - Cell, 2021 - cell.com
Nonalcoholic fatty liver disease (NAFLD) is the leading chronic liver disease worldwide. Its
more advanced subtype, nonalcoholic steatohepatitis (NASH), connotes progressive liver …

[HTML][HTML] Intestinal barrier in human health and disease

N Di Tommaso, A Gasbarrini, FR Ponziani - International journal of …, 2021 - mdpi.com
The intestinal mucosa provides a selective permeable barrier for nutrient absorption and
protection from external factors. It consists of epithelial cells, immune cells and their …

The intestinal microbiota fuelling metabolic inflammation

H Tilg, N Zmora, TE Adolph, E Elinav - Nature Reviews Immunology, 2020 - nature.com
Low-grade inflammation is the hallmark of metabolic disorders such as obesity, type 2
diabetes and nonalcoholic fatty liver disease. Emerging evidence indicates that these …

The role of macrophages in nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

K Kazankov, SMD Jørgensen, KL Thomsen… - Nature reviews …, 2019 - nature.com
Nonalcoholic fatty liver disease (NAFLD) and its inflammatory and often progressive subtype
nonalcoholic steatohepatitis (NASH) are becoming the leading cause of liver-related …

[HTML][HTML] Intestinal barrier and permeability in health, obesity and NAFLD

P Portincasa, L Bonfrate, M Khalil, MD Angelis… - Biomedicines, 2021 - mdpi.com
The largest surface of the human body exposed to the external environment is the gut. At this
level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal …

The links between the gut microbiome and non-alcoholic fatty liver disease (NAFLD)

Z Safari, P Gérard - Cellular and Molecular Life Sciences, 2019 - Springer
NAFLD is currently the main cause of chronic liver disease in developed countries, and the
number of NAFLD patients is growing worldwide. NAFLD often has similar symptoms to …

The gut microbiome and liver cancer: mechanisms and clinical translation

LX Yu, RF Schwabe - Nature reviews Gastroenterology & hepatology, 2017 - nature.com
Hepatocellular carcinoma (HCC) is the third leading cause of worldwide cancer mortality.
HCC almost exclusively develops in patients with chronic liver disease, driven by a vicious …

Recent insights into the pathogenesis of nonalcoholic fatty liver disease

JP Arab, M Arrese, M Trauner - Annual Review of Pathology …, 2018 - annualreviews.org
Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide and an
important risk factor for both hepatic and cardiometabolic mortality. The rapidly increasing …

[HTML][HTML] The role of gut microbiota in the development of obesity and diabetes

OA Baothman, MA Zamzami, I Taher… - Lipids in health and …, 2016 - Springer
Obesity and its associated complications like type 2 diabetes (T2D) are reaching epidemic
stages. Increased food intake and lack of exercise are two main contributing factors. Recent …

[HTML][HTML] Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease

C Jiang, C Xie, F Li, L Zhang… - The Journal of …, 2015 - Am Soc Clin Investig
Nonalcoholic fatty liver disease (NAFLD) is a major worldwide health problem. Recent
studies suggest that the gut microbiota influences NAFLD pathogenesis. Here, a murine …