Sources of DNA double-strand breaks and models of recombinational DNA repair
A Mehta, JE Haber - Cold Spring Harbor perspectives in …, 2014 - cshperspectives.cshlp.org
DNA is subject to many endogenous and exogenous insults that impair DNA replication and
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …
proper chromosome segregation. DNA double-strand breaks (DSBs) are one of the most …
The role of nitric oxide in cancer: master regulator or NOt?
FH Khan, E Dervan, DD Bhattacharyya… - International journal of …, 2020 - mdpi.com
Nitric oxide (NO) is a key player in both the development and suppression of tumourigenesis
depending on the source and concentration of NO. In this review, we discuss the …
depending on the source and concentration of NO. In this review, we discuss the …
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells
Accumulating evidence suggests that exogenous cellular stress induces PD-L1 upregulation
in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but …
in cancer. A DNA double-strand break (DSB) is the most critical type of genotoxic stress, but …
Metabolic regulation of homologous recombination repair by MRE11 lactylation
Lactylation is a lactate-induced post-translational modification best known for its roles in
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …
epigenetic regulation. Herein, we demonstrate that MRE11, a crucial homologous …
DNA-PK: a dynamic enzyme in a versatile DSB repair pathway
DNA double stranded breaks (DSBs) are the most cytoxic DNA lesion as the inability to
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
properly repair them can lead to genomic instability and tumorigenesis. The prominent DSB …
53BP1, BRCA1, and the choice between recombination and end joining at DNA double-strand breaks
JM Daley, P Sung - Molecular and cellular biology, 2014 - Taylor & Francis
When DNA double-strand breaks occur, the cell cycle stage has a major influence on the
choice of the repair pathway employed. Specifically, nonhomologous end joining is the …
choice of the repair pathway employed. Specifically, nonhomologous end joining is the …
Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography
LH Thompson - Mutation Research/Reviews in Mutation Research, 2012 - Elsevier
The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …
[HTML][HTML] The multifaceted roles of Ku70/80
S Zahid, M Seif El Dahan, F Iehl… - International Journal of …, 2021 - mdpi.com
DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …
Coordinated nuclease activities counteract Ku at single-ended DNA double-strand breaks
P Chanut, S Britton, J Coates, SP Jackson… - Nature …, 2016 - nature.com
Repair of single-ended DNA double-strand breaks (seDSBs) by homologous recombination
(HR) requires the generation of a 3′ single-strand DNA overhang by exonuclease activities …
(HR) requires the generation of a 3′ single-strand DNA overhang by exonuclease activities …
Mechanisms of telomere loss and their consequences for chromosome instability
K Muraki, K Nyhan, L Han, JP Murnane - Frontiers in oncology, 2012 - frontiersin.org
The ends of chromosomes in mammals, called telomeres, are composed of a 6-bp repeat
sequence, TTAGGG, which is added on by the enzyme telomerase. In combination with a …
sequence, TTAGGG, which is added on by the enzyme telomerase. In combination with a …