The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Interlocking gene mutations, epigenetic alterations and microenvironmental features
perpetuate tumor development, growth, infiltration and spread. Consequently, intrinsic and …

Based on its potent capacity to induce tumor cell death and to abrogate clonogenic survival,
radiotherapy is a key part of multimodal cancer treatment approaches. Numerous clinical …

Glioblastoma is a severe type of primary brain tumor, and its highly invasive character is
considered to be a major therapeutic obstacle. Several recent studies have reported that …

Alterations in mechano-physiological properties of a tissue instigate cancer burdens in
parallel to common genetic and epigenetic alterations. The chronological and mechanistic …

Among all solid tumors, the high‐grade glioma appears to be the most vascularized one. In
fact,“microvascular hyperplasia” is a hallmark of GBM. An altered vascular network …

Particle radiotherapy such as proton and carbon ion has been producing promising clinical
results worldwide. The purpose of this study was to compare metastatic capabilities of …

Abstract β3 integrin (ITGB3), also known as CD61 or GP3A, is one of the most widely studied
components in the integrin family. As an adhesion receptor on the cell surface, ITGB3 …

The survival of cancer patients suffering from glioblastoma multiforme is limited to just a few
months even after treatment with the most advanced techniques. The indefinable borders of …

The biological effects of ionizing radiation are exploited in the clinical practice of
radiotherapy to destroy tumour cells while sparing the surrounding normal tissue. While …