Cell lines are valuable resources as model for human biology and translational medicine. It
is thus important to explore the concordance between the expression in various cell lines vis …

Background Lung adenocarcinoma (LUAD) is the one of the most common subtypes in lung
cancer. Although various targeted therapies have been used in the clinical practice, the 5 …

Doxorubicin (DOX) is an anthracycline antineoplastic agent that has limited clinical utility
due to its dose-dependent cardiotoxicity. Although the exact mechanism remains unknown …

Motivation Many approaches in systems biology have been applied in drug repositioning
due to the increased availability of the omics data and computational biology tools. Using a …

Background Despite numerous clinical trials and decades of endeavour, there is still no
effective cure for Alzheimer's disease. Computational drug repositioning approaches may be …

Background: Despite the increasing prevalence rate of nonalcoholic fatty liver disease
(NAFLD) worldwide, efficient pharmacotherapeutic regimens against NAFLD still need to be …

Activated de novo lipogenesis (DNL) is the critical pathway involved in the progression of
metabolic-associated fatty liver disease (MAFLD). We present an in vitro steatosis model for …

Sarcopenia is a major public health concern among older adults, leading to disabilities, falls,
fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of …

In this study, we observed worsening metabolic crosstalk in mouse models with concomitant
metabolic disorders such as hyperhomocysteinemia (HHcy), hyperlipidemia, and …

Glioblastoma (GBM), a highly malignant tumour of the central nervous system, presents with
a dire prognosis and low survival rates. The heterogeneous and recurrent nature of GBM …