Several experimental and epidemiological evidence indicate that, irrespective of the trigger
for the development (chronic infection/inflammation or genetic alteration), a “smouldering” …

Adipocytes are important but underappreciated components of bone marrow
microenvironment, and their numbers greatly increase with age, obesity, and associated …

To assess anti-tumor activity of sequential epirubicin/cyclophosphamide followed by
docetaxel with the randomized addition of celecoxib in HER2 negative patients or …

Background As therapies for systemic cancer improve and patients survive longer, the risk
for brain metastases increases. We evaluated whether immune mechanisms are involved in …

Pre‑clinical and on‑going trials have indicated the advantage of using metformin as an
anticancer drug alone or in combination with other chemotherapeutics for the treatment of …

Feline mammary tumours comprise approximately 11% of feline non-integumentary
neoplasms, are more commonly malignant than benign, and carry a poor prognosis …

Tumor metastasis to bone is a common event in multiple forms of malignancy. Inflammation
holds essential functions in homeostasis as a defense mechanism against infections and is …

The purpose of this meta-analysis was to evaluate the efficacy and safety of celecoxib, a
selective cyclooxygenase-2 (COX-2) inhibitor, in addition to standard anticancer therapy …

To determine the significance of (Cyclooxygenase 2) COX2 for clinical outcome in breast
cancer, we analyzed the correlation between COX2 overexpression and survival in 687 …

Every year more than a million new cancer cases and 600,000 deaths are reported world-
wide. Colorectal cancer is the fourth most commonly occurring and second leading cause of …