The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Context: Lipodystrophies are heterogeneous, genetic or acquired disorders characterized by
selective loss of body fat and predisposition to insulin resistance. The extent of fat loss …

Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by
features reminiscent of marked premature ageing,. Here, we present evidence of mutations …

This paper presents the 12th update of the human obesity gene map, which incorporates
published results up to the end of October 2005. Evidence from single‐gene mutation …

Lipodystrophies, heterogeneous acquired or inherited disorders characterized by the
selective loss of adipose tissue, predispose affected patients to insulin resistance and its …

Nuclear lamins are intermediate filament proteins that polymerize to form the nuclear lamina
on the inner aspect of the inner nuclear membrane. Long known to be essential for …

Mutations in genes encoding the intermediate filament nuclear lamins and associated
proteins cause a wide spectrum of diseases sometimes called “laminopathies.” Diseases …

Nuclear lamins were initially identified as the major components of the nuclear lamina, a
proteinaceous layer found at the interface between chromatin and the inner nuclear …

Objectives: We examined the prevalence, genotype-phenotype correlation, and natural
history of lamin A/C gene (LMNA) mutations in subjects with dilated cardiomyopathy (DCM) …

Few genes have generated as much recent interest as LMNA, LMNB1 and LMNB2, which
encode the components of the nuclear lamina. Over 180 mutations in these genes are …