[HTML][HTML] Obesity-associated alterations of natural killer cells and immunosurveillance of cancer

I Bähr, J Spielmann, D Quandt, H Kielstein - Frontiers in immunology, 2020 - frontiersin.org
Obesity is accompanied by a systemic chronic low-grade inflammation as well as
dysfunctions of several innate and adaptive immune cells. Recent findings emphasize an …

[HTML][HTML] Natural killer cell dysfunction in hepatocellular carcinoma and NK cell-based immunotherapy

C Sun, H Sun, W Xiao, C Zhang, Z Tian - Acta Pharmacologica Sinica, 2015 - nature.com
The mechanisms linking hepatitis B virus (HBV) and hepatitis C virus (HCV) infection to
hepatocellular carcinoma (HCC) remain largely unknown. Natural killer (NK) cells account …

High NKG2A expression contributes to NK cell exhaustion and predicts a poor prognosis of patients with liver cancer

C Sun, J Xu, Q Huang, M Huang, H Wen… - …, 2017 - Taylor & Francis
ABSTRACT Background and Aims: As the predominant lymphocyte subset in the liver,
natural killer (NK) cells have been shown to be highly associated with the outcomes of …

Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections

B Oliviero, S Varchetta, E Paudice, G Michelone… - Gastroenterology, 2009 - Elsevier
BACKGROUND & AIMS: The phenotypic and functional characteristics of natural killer (NK)
cells in chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are …

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

C Sun, H Sun, C Zhang, Z Tian - Cellular & molecular immunology, 2015 - nature.com
Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa–dependent manner

G Ahlenstiel, RH Titerence, C Koh, B Edlich, JJ Feld… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Patients with chronic hepatitis C virus (HCV) infection display great
variability in disease activity and progression. Although virus-specific adaptive immune …

[HTML][HTML] CD161 defines a functionally distinct subset of pro-inflammatory natural killer cells

A Kurioka, C Cosgrove, Y Simoni… - Frontiers in …, 2018 - frontiersin.org
CD161 is a C-type lectin-like receptor expressed on the majority of natural killer (NK) cells;
however, the significance of CD161 expression on NK cells has not been comprehensively …

KIR and disease: a model system or system of models?

SI Khakoo, M Carrington - Immunological reviews, 2006 - Wiley Online Library
The discovery of an unexpected level of diversity among the killer cell immunoglobulin‐like
receptors has led to a search for their role in human disease. Due to their polymorphism and …

Natural killer cells in HIV-1 infection and therapy

J Mikulak, F Oriolo, E Zaghi, C Di Vito, D Mavilio - Aids, 2017 - journals.lww.com
Natural killer (NK) cells are important effectors of innate immunity playing a key role in the
eradication and clearance of viral infections. Over the recent years, several studies have …

Activation of natural killer cells during acute infection with hepatitis C virus

B Amadei, S Urbani, A Cazaly, P Fisicaro, A Zerbini… - Gastroenterology, 2010 - Elsevier
BACKGROUND & AIMS: Natural killer (NK) cells are essential early after infection, not only
for viral containment but also for timely and efficient induction of adaptive responses. An …