Chemistry of MRI contrast agents: current challenges and new frontiers

J Wahsner, EM Gale, A Rodríguez-Rodríguez… - Chemical …, 2018 - ACS Publications
Tens of millions of contrast-enhanced magnetic resonance imaging (MRI) exams are
performed annually around the world. The contrast agents, which improve diagnostic …

Recent advances in Gd-chelate based bimodal optical/MRI contrast agents

P Verwilst, S Park, B Yoon, JS Kim - Chemical Society Reviews, 2015 - pubs.rsc.org
Research on bimodal contrast agents in general and optical/MRI contrast agents in
particular has attracted increased attention from the scientific community in recent years …

[图书][B] Materials for Biomedical Engineering: Inorganic Micro-and Nanostructures

V Grumezescu, A Grumezescu - 2019 - books.google.com
Materials for Biomedical Engineering: Inorganic Micro-and Nanostructures presents recent,
specific insights in new progress, along with new perspectives for inorganic micro-and nano …

Imaging Insulin Secretion from Mouse Pancreas by MRI Is Improved by Use of a Zinc-Responsive MRI Sensor with Lower Affinity for Zn2+ Ions

AF Martins, V Clavijo Jordan, F Bochner… - Journal of the …, 2018 - ACS Publications
It has been demonstrated that divalent zinc ions packaged with insulin in β-cell granules can
be detected by MRI during glucose-stimulated insulin secretion using a gadolinium-based …

Amplifying the sensitivity of zinc (II) responsive MRI contrast agents by altering water exchange rates

J Yu, AF Martins, C Preihs… - Journal of the …, 2015 - ACS Publications
Given the known water exchange rate limitations of a previously reported Zn (II)-sensitive
MRI contrast agent, GdDOTA-diBPEN, new structural targets were rationally designed to …

Metal-involved theranostics: An emerging strategy for fighting Alzheimer's disease

X Wang, X Wang, Z Guo - Coordination Chemistry Reviews, 2018 - Elsevier
Alzheimer's disease (AD) is the most prevalent illness among the neurodegenerative
disorders that are progressive, irreversible and incurable so far. Although the etiological …

Amyloid β-targeted metal complexes for potential applications in Alzheimer's disease

H Liu, Y Qu, X Wang - Future medicinal chemistry, 2018 - Taylor & Francis
Alzheimer's disease (AD) is currently an incurable neurodegenerative disorder that affects
millions of people around the world. The aggregation of amyloid-β peptides (Aβ), one of the …

Strategies for the molecular imaging of amyloid and the value of a multimodal approach

A Kaur, EJ New, M Sunde - ACS sensors, 2020 - ACS Publications
Protein aggregation has been widely implicated in neurodegenerative diseases such as
Alzheimer's disease, frontotemporal dementia, Parkinson's disease, and Huntington …

A theranostic agent combining a two‐photon‐absorbing photosensitizer for photodynamic therapy and a gadolinium (III) complex for MRI detection

J Schmitt, V Heitz, A Sour, F Bolze… - … A European Journal, 2016 - Wiley Online Library
The convergent synthesis and characterization of a potential theranostic agent,[DPP‐ZnP‐
GdDOTA]−, which combines a diketopyrrolopyrrole‐porphyrin component DPP‐ZnP as a …

Synthesis and characterization of a stable and inert Mn II-based Zn II responsive MRI probe for molecular imaging of glucose stimulated zinc secretion (GSZS)

R Botár, E Molnár, Z Garda, E Madarasi… - Inorganic Chemistry …, 2022 - pubs.rsc.org
A new potential ZnII responsive MnII-based MRI CA candidate derived from pyclen-3, 9-
diacetate (3, 9-PC2A) has been synthesized and it possesses a di-(2-picolyl) amine (DPA) …