The intestinal epithelium is replenished every 3-4 days through an orderly process that
maintains important secretory and absorptive functions while preserving a continuous …

Esophageal adenocarcinoma (EAC) is one of the most frequent causes of cancer death, and
yet compared to other common cancers, we know relatively little about the molecular …

Background The epithelial lining of the human epididymis is critical for sperm maturation.
This process requires distinct specialized functions in the head, body, and tail of the duct …

The incidence of early-onset colorectal cancer (EO-CRC) is rising and is poorly understood.
Lifestyle factors and altered genetic background possibly contribute. Here, we performed …

Immune-related etiologic pathways to influence invasive breast cancer risk may interact with
lifestyle factors, but the interrelated molecular genetic pathways are incompletely …

Drug bioavailability studies commonly employ in vitro barrier tissue models consisting of
epithelial and endothelial cells. These experiments require that the cell barrier quality be …

Ageing is a major risk factor for various forms of liver and gastrointestinal (GI) disease and
genetic background may contribute to the pathogenesis of these diseases. Group VIA …

Abstract Motivation The Human Reference Epigenome Map, generated by the Roadmap
Epigenomics Consortium, contains thousands of genome-wide epigenomic datasets that …

The hepatocyte nuclear factor-1 (HNF1ɑ) is a transcription factor that contributes to several
kinds of cancer progression. However, very little is known regarding the mechanisms …

About 8% of the human genome is covered with candidate cis-regulatory elements (cCREs).
Disruptions of CREs, described as “cis-ruptions” have been identified as being involved in …