Background: 6-mercaptopurine (6-MP) is an essential component of pediatric acute
lymphoblastic leukemia (ALL) maintenance therapy. Individual variability in this drug-related …

Background and Aims It has been demonstrated that heterozygote and homozygote
thiopurine S-methyltransferase (TPMT) mutant allele carriers are at high risk to develop …

Methods: We included 52 ALL childhood cases from King Hussein Cancer Research Center
in Jordan. Genotyping of the rs1800460, rs1800462, and rs1142345 SNPs was performed …

Background The aim of the present study is to determine the correlation of hepatitis C virus
(HCV) infection and polymorphisms in different genes with toxicity of either methotrexate …

Akın DF, Aşlar-Öner D, Kürekçi E, Akar N. Frequency of thiopurine S-methyltransferase gene
variations in Turkish children with acute leukemia. Turk J Pediatr 2018; 60: 147-152. In this …

Malignant gastric teratoma in a 3-month-old infant Page 1 İ 2015 Indian Journal of Medical and
Paediatric Oncology | Published by Wolters Kluwer - Medknow 271 A 3-month-old boy presented …

Thiopurine methyltransferase (TPMT) gene polymorphism regulates thiopurine therapeutic
efficacy and toxicity. The aim of this study was to determine the influence of TPMT gene …

Results In the patients group, 97.5% were of the wild-type homozygous TPMT* 1/* 1
genotype and 2.5% were of the heterozygous TPMT* 1/* 3A genotype. In the control group …

Aim: Thiopurine S-methyltransferase (TPMT) is an essential enzyme in the metabolism of
thiopurine drugs, and its activity may change due to different polymorphisms in the TPMT …

Background: Thiopurines are essential medications in Acute Lymphoblastic Leukemia (ALL)
treatment protocols as anti-cancer agents since long time; however, their use might result in …