The heart is a rhythmic electromechanical pump, the functioning of which depends on action
potential generation and propagation, followed by relaxation and a period of refractoriness …

In the mammalian heart, Ca2+‐independent, depolarization‐activated potassium (K+)
currents contribute importantly to shaping the waveforms of action potentials, and several …

Since the first discovery of Kvβ-subunits more than 15 years ago, many more ancillary Kv
channel subunits were characterized, for example, KChIPs, KCNEs, and BKβ-subunits. The …

The expression of 15 different K+ channels in canine heart was examined, and a new K+
channel gene (Kv4. 3), which encodes a rapidly inactivating K+ current, is described. The …

Dendritic, backpropagating action potentials (bAPs) facilitate the induction of Hebbian long-
term potentiation (LTP). Although bAPs in distal dendrites of hippocampal CA1 pyramidal …

▪ Abstract Potassium channels contribute to the excitability of neurons and signaling in the
nervous system. They arise from multiple gene families including one for voltage-gated …

The human ether à-go-go-related gene (HERG) encodes a K+ channel that is believed to be
the basis of the delayed rectified current, IKr, in cardiac muscle. We studied HERG …

At least two functionally distinct transient outward K+ current (Ito) phenotypes can exist
across the free wall of the left ventricle (LV). Based upon their voltage‐dependent kinetics of …

Chronic hypoxia depolarizes and reduces K+ current in pulmonary arterial smooth muscle
cells (PASMCs). Our laboratory previously demonstrated that hypoxia-inducible factor-1 (HIF …

Inactivation is the process by which an open channel enters a stable nonconducting
conformation after a depolarizing change in membrane potential. Inactivation is a …