Breast cancer: a molecularly heterogenous disease needing subtype-specific treatments

U Testa, G Castelli, E Pelosi - Medical Sciences, 2020 - mdpi.com
Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

Anticancer or carcinogenic? The role of estrogen receptor β in breast cancer progression

K Shen, H Yu, B Xie, Q Meng, C Dong, K Shen… - Pharmacology & …, 2023 - Elsevier
Estrogen receptor β (ERβ) is closely related to breast cancer (BC) progression. Traditional
concepts regard ERβ as a tumor suppressor. As studies show the carcinogenic effect of …

CIBERSORT analysis of TCGA and METABRIC identifies subgroups with better outcomes in triple negative breast cancer

KE Craven, Y Gökmen-Polar, SS Badve - Scientific Reports, 2021 - nature.com
Studies have shown that the presence of tumor infiltrating lymphocytes (TILs) in Triple
Negative Breast Cancer (TNBC) is associated with better prognosis. However, the molecular …

Estrogen actions in triple-negative breast cancer

O Treeck, S Schüler-Toprak, O Ortmann - Cells, 2020 - mdpi.com
Triple-negative breast cancer (TNBC) lacks estrogen receptor (ER) α, but the expression of
estrogen receptors ERβ and G protein-coupled estrogen receptor 1 (GPER-1) is able to …

[HTML][HTML] Cancer-associated fibroblasts secreted miR-103a-3p suppresses apoptosis and promotes cisplatin resistance in non-small cell lung cancer

H Wang, H Huang, L Wang, Y Liu, M Wang… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
Background: The cisplatin resistance of non-small cell lung cancer (NSCLC) patients results
in low response rate and overall survival rate. Exosomes contribute to pathological …

The role of estrogen receptor beta in breast cancer

Y Zhou, X Liu - Biomarker research, 2020 - Springer
Breast cancer, a malignant tumor originating from mammary epithelial tissue, is the most
common cancer among women worldwide. Challenges facing the diagnosis and treatment …

Estrogens and progestogens in triple negative breast cancer: do they harm?

M van Barele, BAM Heemskerk-Gerritsen, YV Louwers… - Cancers, 2021 - mdpi.com
Simple Summary Young women treated for breast cancer may experience early
menopause, which can negatively impact quality of life. The usual treatment for early …

[HTML][HTML] CRISPR/Cas9 based genome editing for targeted transcriptional control in triple-negative breast cancer

DD Singh, I Han, EH Choi, DK Yadav - Computational and structural …, 2021 - Elsevier
Breast cancer (BC) is the most common type of cancer in women at the global level and the
highest mortality rate has been observed with triple-negative breast cancer (TNBC) …

Estrogen receptor β4 regulates chemotherapy resistance and induces cancer stem cells in triple negative breast cancer

A Bano, JH Stevens, PS Modi, JÅ Gustafsson… - International Journal of …, 2023 - mdpi.com
Triple Negative Breast Cancer (TNBC) has the worst prognosis among all breast cancers,
and survival in patients with recurrence is rarely beyond 12 months due to acquired …

The Potential of Hormonal Therapies for Treatment of Triple-Negative Breast Cancer

M Kirkby, AM Popatia, JR Lavoie, L Wang - Cancers, 2023 - mdpi.com
Simple Summary The presence of estrogen receptor beta, the androgen receptor, and the
glucocorticoid receptor on triple-negative breast cancer cells has opened the possibility for …